The impact of digital healthcare systems on pain and body function in patients with knee joint pain: a systematic review and meta-analysis.

The digital healthcare (DH) system has recently emerged as an advanced rehabilitation approach that promotes rehabilitation training based on virtual reality (VR) and augmented reality (AR). The purpose of this meta-analysis study is to review and assess the impact of DH systems on pain and physical function among patients diagnosed with knee joint pain. Between January 2003 and September 2023, studies that met the listed inclusion criteria were gathered from Scopus, PubMed, Web of Science, and EBSCO databases. The analysis of standardized mean difference (SMD) was carried out with 95% confidence interval (95% CI) (PROSPERO registration number: CRD42023462538). Eight research papers were selected, which collectively involved 194 males and 279 females. The meta-analysis outcomes revealed that DH intervention significantly improved balance (SMD, 0.41 [0.12, 0.69], p < 0.05) and pain level (SMD, - 1.10 [- 2.02, - 0.18], p < 0.05). The subgroup analysis of the pain level showed varied outcomes for the TKA (SMD, - 0.22 [- 0.49, 0.04], p = 0.10) or OA patients (SMD, - 2.80 [- 3.83, - 1.78], p < 0.05) Next, this study found no significant effect of DH intervention on knee joint range of motion (ROM) (SMD, 0.00 [- 0.76, 0.76], p = 1.00) and walking velocity (SMD, 0.04 [- 0.22, 0.29], p = 0.77) in patients with knee joint pain. The meta-analysis review conducted in this study revealed that DH intervention may potentially improve balance among the patients with knee joint pain. It may also alleviate the pain level particularly among OA patients.

Why are there no girls? Increasing children's recognition of structural causes of the gender gap in STEM.

The gender disparity in STEM fields emerges early in development. This research examined children's explanations for this gap and investigated two approaches to enhance children's structural understanding that this imbalance is caused by societal, systematic barriers. Five- to 8-year-old children (N = 145) observed girls' underrepresentation in a STEM competition; the No Structural Information condition presented no additional information, the Structural: Between-Group Comparison (Between) condition compared boys' greater representation to girls' when boys had more opportunities to practice than girls, and the Structural: Within-Group Comparison (Within) condition compared girls' greater STEM representation when they had opportunities versus not. Children in the No Structural condition largely generated intrinsic explanations; in contrast, children in both structural conditions favored structural explanations for girls' lack of participation (Experiment 1) and achievement (Experiment 2). Importantly, each structural condition also had unique effects: Between raised children's fairness concerns, while Within increased children's selection of girls as teammates in a competitive STEM activity.

The development and predictors of a preference for strivers over naturals in the United States and China.

Across three pre-registered studies (n = 221 4-9-year olds, 51% female; 218 parents, 80% female; working- and middle-class backgrounds; data collected during 2019-2021) conducted in the United States (Studies 1-2; 74% White) and China (Study 3; 100% Asian), we document the emergence of a preference for "strivers." Beginning at age 7, strivers (who work really hard) were favored over naturals (who are really smart) in both cultures (R2 ranging .03-.11). We explored several lay beliefs surrounding this preference. Beliefs about outcomes and the controllability of effort predicted the striver preference: Children who expected strivers to be more successful than naturals and believed effort was more controllable than talent preferred strivers more. Implications of the striver preference in education and beyond are discussed.

The impact of sufferers' wealth status on pain perceptions: Its development and relation to allocation of healthcare resources.

Wealth-based disparities in health care wherein the poor receive undertreatment in painful conditions are a prominent issue that requires immediate attention. Research with adults suggests that these disparities are partly rooted in stereotypes associating poor individuals with pain insensitivity. However, whether and how children consider a sufferer's wealth status in their pain perceptions remains unknown. The present work addressed this question by testing 4- to 9-year-olds from the US and China. In Study 1 (N = 108, 56 girls, 79% White), US participants saw rich and poor White children experiencing identical injuries and indicated who they thought felt more pain. Although 4- to 6-year-olds responded at chance, children aged seven and above attributed more pain to the poor than to the rich. Study 2 with a new sample of US children (N = 111, 56 girls, 69% White) extended this effect to judgments of White adults' pain. Pain judgments also informed children's prosocial behaviors, leading them to provide medical resources to the poor. Studies 3 (N = 118, 59 girls, 100% Asian) and 4 (N = 80, 40 girls, 100% Asian) found that, when evaluating White and Asian people's suffering, Chinese children began to attribute more pain to the poor than to the rich earlier than US children. Thus, unlike US adults, US children and Chinese children recognize the poor's pain from early on. These findings add to our knowledge of group-based beliefs about pain sensitivity and have broad implications on ways to promote equitable health care. RESEARCH HIGHLIGHTS: Four studies examined whether 4- to 9-year-old children's pain perceptions were influenced by sufferers' wealth status. US children attributed more pain to White individuals of low wealth status than those of high wealth status by age seven. Chinese children demonstrated an earlier tendency to attribute more pain to the poor (versus the rich) compared to US children. Children's wealth-based pain judgments underlied their tendency to provide healthcare resources to people of low wealth status.

Gender brilliance stereotype emerges early and predicts children's motivation in South Korea.

Recent work suggests that the stereotype associating brilliance with men may underpin women's underrepresentation in prestigious careers, yet little is known about its development and consequences in non-Western contexts. The present research examined the onset of this stereotype and its relation to children's motivation in 5- to 7-year-old Korean children (N = 272, 50% girls, tested 2021 to 2022). At age 7, children attributed brilliance to men when evaluating Asians and Whites, and girls became less interested in participating in intellectually challenging tasks than boys. Notably, this gender difference in interest was mediated by children's endorsement of the stereotype. The generalizable early emergence of the gender brilliance stereotype and its detrimental implications press the need to tackle gender imbalance in early childhood.

Development of a novel bispecific antibody GR1801 for rabies.

Rabies is a zoonotic viral disease characterized by an almost 100% fatality rate once symptoms appear. However, it can be prevented through timely postexposure prophylaxis (PEP). Currently, there is a growing trend to replace polyclonal rabies immune globulin (RIG) with monoclonal antibodies (mAbs) in rabies PEP. In this study, we developed a human bispecific antibody, GR1801, by combining two mAbs, A2 and B353, which target distinct epitopes. GR1801 is an asymmetric immunoglobulin G1 molecule, with one arm (A2 targeting epitope III) in fragment antigen-binding (Fab) form and the other arm (B353 targeting epitope I) in single-chain variable fragment (scFv) form, constructed using Knobs-into-Holes technology. GR1801 demonstrated the ability to neutralize 90 naturally occurring rabies virus (RABV) glycoprotein antigenic variants, 21 pseudotyped, and 18 live street RABVs, exhibiting broad-spectrum neutralizing activity. In vivo, GR1801 provided protection equivalent to that of human RIG in golden hamsters challenged with lethal RABV. In conclusion, these findings demonstrate the neutralization potency and breadth of GR1801, which can be a promising candidate drug for rabies PEP, and a comprehensive testing against a broad spectrum of Chinese prevalent RABVs will be investigated in great detail in the future for the in vitro and in vivo studies.

Should leaders conform? Developmental evidence from the United States and China.

Leadership is inextricably embedded in human groups. One central obligation of leaders is to embody the identity of their group by acting in line with group norms. Yet little is known about how leadership and conformity are initially associated in people's minds, how this association develops in childhood, and how cultural values shape this association. The present research tested 4- to 11-year-olds in the United States and China to address these questions by comparing children's evaluations of a leader's versus an ordinary group member's nonconformity. In Experiments 1 and 3 (N = 114 and 116, respectively), children saw two novel groups engage in distinct behaviors (e.g., listening to different kinds of music). A leader or a nonleader acted against their respective group norms. Next, children provided evaluations of the nonconformity. In both populations, whereas younger children (4- to 7-year-olds) evaluated the leader's nonconformity more positively relative to the nonleader's, older children (10- to 11-year-olds) evaluated the leader's nonconformity more negatively. Notably, children in China developed more negative attitudes toward a leader's nonconformity than children in the United States. Experiment 2 (N = 66) ruled out the possibility that younger children's favorable evaluations of the leader's nonconformity stemmed from their general positivity toward leaders. Taken together, children in the two countries gradually conceptualize leaders as central group members and expect them to follow group norms. These findings contribute to theories on early leadership cognition and highlight the importance of taking a cross-cultural approach to understand its development. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Children can represent complex social status hierarchies: Evidence from Indonesia.

Children's ethnicity-status associations are often studied in societies where one ethnic group possesses status across multiple dimensions, such as political influence and wealth. This study examined children's (6-12 years) and adults' representations of more complex hierarchies in Indonesia (N = 341; 38% Native Indonesian, 33% Chinese Indonesian, and 27% other ethnicities; 55% female, 36% male; 2021-2022), a society where ethnic groups hold distinct forms of status (on average, Native Indonesians have political influence; Chinese Indonesians have wealth). By 6.5 years, children associated Native Indonesians with political influence and Chinese Indonesians with wealth. Intersectional analyses indicated that ethnicity-status associations were stronger for male than female targets. Children of all ethnicities preferred Chinese Indonesians and preferences were predicted by wealth judgments.

Expression of PLCH1 gene in esophageal squamous cell carcinoma and its effect on cell proliferation and migration / 中国生物制品学杂志

@#ObjectiveTo detect the gene variation and expression of PLCH1 in esophageal squamous cell carcinoma(ESCC),analyze the function of PLCH1 gene in ESCC and explore its mechanism.MethodsThe copy number variation of PLCH1 in ESCC was analyzed by GISTIC,and the expression of PLCH1 in ESCC and normal esophageal tissues was detected by TCGA database and immunohistochemistry method. The expression of PLCH1 in ESCC cell lines was detected by real-time fluorescence quantitative PCR(qPCR) and Western blot,and the effects of PLCH1 silencing on the proliferation and migration of ESCC cells were detected by MTT assay,colony formation assay and Transwell assay.Results There was significant copy number amplification of PLCH1 in ESCC(G-scores > 0. 1,P < 0. 05),and the expression levels of PLCH1 mRNA and protein in ESCC were significantly higher than those in normal tissues(F = 36. 00 ～ 1 101. 00respectively,each P < 0. 000 1). After PLCH1 silencing,the ability of proliferation,clone formation and migration of ESCC cells KYESE180 and TE-9 decreased significantly(F = 35. 49 ～ 634. 00 respectively,each P < 0. 001).Conclusion PLCH1 plays an oncogenic role in ESCC,which is of great significance for the metastasis and proliferation of ESCC,and can be used as a potential target for the treatment of ESCC.

Walking in Her Shoes: Pretending to Be a Female Role Model Increases Young Girls' Persistence in Science.

Pretend play is a ubiquitous learning tool in early childhood, enabling children to explore possibilities outside of their current reality. Here, we demonstrate how pretend play can be leveraged to empower girls in scientific domains. American children ages 4 to 7 years (N = 240) played a challenging science activity in one of three conditions. Children in the exposure condition heard about a successful gender-matched scientist, children in the roleplay condition pretended to be that scientist, and children in the baseline condition did not receive information about the scientist. Girls in the roleplay condition, but not in the exposure condition, persisted longer in the science activity than girls in the baseline condition. Pretending to be the scientist equated girls' persistence to that of boys. These findings suggest that pretend play of role models motivates young girls in science and may help reduce gender gaps from their roots.

Exceptional response of skin symptoms to secukinumab treatment in a patient with SAPHO syndrome: Case report and literature review.

RATIONALE: SAPHO syndrome is a rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Treatment strategies are not standardized. Palmoplantar pustulosis (PPP) is the most common rash in patients with SAPHO syndrome. PATIENT CONCERNS: A 24-year-old Chinese woman with no relevant medical or familial history had a 1-year history of cutaneous lesions with PPP and pain in the sternoclavicular joint. DIAGNOSIS: Based on the diagnostic criteria for SAPHO syndrome proposed by Nguyen et al in 2012, we diagnosed SAPHO syndrome with severe PPP as the predominant manifestation. INTERVENTIONS: Due to the limited therapeutic efficacy of methotrexate and cyclosporin, we started therapy with subcutaneous secukinumab 150 mg weekly for the first month, then 150 mg monthly thereafter. OUTCOMES: After 4 weeks of secukinumab administration, the patient showed significant remission of pustular skin lesions, with almost no joint pain and no adverse reaction. Complete remission of skin symptoms was achieved after 3 months. Joint pain and adverse events have not reoccurred in follow-up thus far. CONCLUSIONS: In patients with SAPHO syndrome, we recommend personalized treatment, which may have excellent therapeutic efficacy in those with PPP or severe skin symptoms. Although data related to the use of IL-17 blockers for SAPHO syndrome are very limited, secukinumab provides a novel therapeutic option, especially for patients with PPP and severe skin lesions. Further prospective studies are needed to support our findings.

Evaluation of Traumatic Subdural Hematoma Volume by Using Image Segmentation Assessment Based on Deep Learning.

Rapid and accurate evaluations of hematoma volume can guide the treatment of traumatic subdural hematoma. We aim to explore the consistency between the measurement results of traumatic subdural hematoma (TSDH) using a deep learn-based image segmentation algorithm. A retrospective study was conducted on 90 CT images of patients diagnosed with TSDH in our hospital from January 2019 to January 2022. All image data were measured by manual segmentation, convolutional neural networks (CNN) algorithm segmentation, and ABC/2 volume formula. With manual segmentation as the "golden standard," a consistency test was carried out with CNN algorithm segmentation and ABC/2 volume formula, respectively. The percentage error of CNN algorithm segmentation is less than ABC/2 volume formula. There is no significant difference between CNN algorithm segmentation and manual segmentation (P > 0.05). The area under curve of the ABC/2 volume formula, manual segmentation, and CNN algorithm segmentation is 0.811 (95% CI: 0.717~0.905), 0.840 (95% CI: 0.753~0.928), and 0.832 (95% CI: 0.742~0.922), respectively. From our results, the algorithm based on CNN has a good efficiency in segmentation and accurate calculation of TSDH hematoma volume.

When Are Similar Individuals a Group? Early Reasoning About Similarity and In-Group Support.

Beginning in infancy, children expect individuals in a group to care for and be loyal to in-group members. One prominent cue that children use to infer that individuals belong to the same group is similarity. Does any salient similarity among individuals elicit an expectation of in-group preference, or does contextual information modulate these expectations? In Experiments 1 and 2, 12-month-old infants expected in-group preference between two individuals who wore the same novel outfit, but they dismissed this similarity if one of the outfits was used to fulfill an instrumental purpose. In Experiment 3, 26-month-old toddlers expected in-group preference between two individuals who uttered the same novel labels, but they dismissed this similarity if the labels were used to convey incidental as opposed to categorical information about the individuals. Together, the results of these experiments (N = 96) provide converging evidence that from early in life, children possess a context-sensitive mechanism for determining whether similarities mark groups.

Gender stereotypes are racialized: A cross-cultural investigation of gender stereotypes about intellectual talents.

In the United States, there is a common stereotype associating brilliance with men. This gender brilliance stereotype emerges early and may undermine women's engagement in many prestigious careers. However, past research on its acquisition has focused almost exclusively on American children's beliefs of White people's intellectual talents. Therefore, less is known about how this stereotype develops in non-Western cultures and whether children consider other social identities such as race in forming this stereotype. To address these issues, the present research (a) provided the first cross-cultural test examining its development in 5- to 7-year-old Chinese and American children and (b) compared children's gender brilliance stereotype of White people with that of Asian people. Studies 1 (N = 96; Chinese children) and 2 (N = 96; Chinese children) revealed that, similar to American children, Chinese children associated brilliance with White men (vs. White women) around the age of 6. In contrast, Studies 3 (N = 96; Chinese children) and 4 (N = 96; American children; 76.9% White) showed that 5- to 7-year-old children from both cultures associated brilliance with Asian women (vs. Asian men). The results suggest that the gender stereotype about brilliance has a racial component and may be culturally consistent. Overall, these findings add to our knowledge of children's acquisition of the gender stereotype about brilliance in non-Western cultural contexts and highlight the importance of considering multiple social identities to understand the acquisition of stereotypes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Who Would the Person Be after a Head Transplant? A Confucian Reflection.

This essay draws on classical Confucian intellectual resources to argue that the person who emerges from a head transplant would be neither the person who provided the head, nor the person who provided the body, but a new, different person. We construct two types of argument to support this conclusion: one is based on the classical Confucian metaphysics of human life as qi activity; the other is grounded in the Confucian view of personal identity as being inseparable from one's familial relations. These Confucian ideas provide a reasonable alternative to the currently dominant view that one's personal identity "follows" one's head. Together, these arguments imply that head transplantation is ethically inappropriate.

Generics about categories and generics about individuals: Same phenomenon or different?

Language can be used to express broad, unquantified generalizations about both categories (e.g., "Dogs bark") and individuals (e.g., "Daisy barks"). Although these two classes of statements are commonly assumed to arise from the same linguistic phenomenon-genericity-the literature to date has not offered a direct experimental comparison of the conditions under which they are endorsed (i.e., their truth conditions). Here, we provide such a comparison by testing whether endorsement of generics about categories and individuals is affected in similar ways by the conceptual content of the properties being generalized. Consistent with this possibility, six experiments (N = 1,265) and an internal meta-analysis reveal that endorsement of generics about both categories and individuals is facilitated when the properties being generalized are distinctive or dangerous, suggesting systematic similarities in the truth conditions of generics about categories and individuals. The experiments also suggest that these facilitative effects do not extend to statements with overt quantification (all/always and some/sometimes). Thus, the present studies provide the first empirical evidence indicating that generics about categories and generics about individuals represent a unified phenomenon. These findings contribute to theories of genericity and inform our understanding of how language shapes social interactions. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Cognitive Impairment of Patient With Neurological Cerebrovascular Disease Using the Artificial Intelligence Technology Guided by MRI.

This study was to explore the application of MRI based on artificial intelligence technology combined with neuropsychological assessment to the cognitive impairment of patients with neurological cerebrovascular diseases. A total of 176 patients were divided into a control group, a vascular cognitive impairment non-dementia (VCIND) group, a vascular dementia (VD) group, and an Alzheimer's disease (AD) group. All patients underwent MRI and neuropsychological evaluation and examination, and an improved fuzzy C-means (FCM) clustering algorithm was proposed for MRI processing. It was found that the segmentation accuracy (SA) and similarity (KI) data of the improved FCM algorithm used in this study were higher than those of the standard FCM algorithm, bias-corrected FCM (BCFCM) algorithm, and rough FCM (RFCM) algorithm (p < 0.05). In the activities of daily living (ADL), the values in the VCIND group (23.55 ± 6.12) and the VD group (28.56 ± 3.1) were higher than that in the control group (19.17 ± 3.67), so the hippocampal volume was negatively correlated with the ADL (r = -0.872, p < 0.01). In the VCIND group (52.4%), VD group (31%), and AD group (26.1%), the proportion of patients with the lacunar infarction distributed on both sides of the brain and the number of multiple cerebral infarction lesions (76.2, 71.4, and 71.7%, respectively) were significantly higher than those in the control group (23.9 and 50%). In short, the improved FCM algorithm showed a higher segmentation effect and SA for MRI of neurological cerebrovascular disease. In addition, the distribution, number, white matter lesions, and hippocampal volume of lacunar cerebral infarction were related to the cognitive impairment of patients with cerebrovascular diseases.

Analysis of Factors Affecting Cranial Nerve Function of Patients With Vascular Mild Cognitive Impairment Through Functional Magnetic Resonance Imaging Under Artificial Intelligence Environment.

The study aimed to explore the risk factors of effects of patients with vascular mild cognitive impairment (VaMCI) through functional magnetic resonance imaging (fMRI). In this study, 62 patients were selected from the department of neurology, admitted to Changzhi People's Hospital from October 1, 2018 to February 1, 2020. Patients with VaMCI were defined as the VaMCI group according to Clinical Dementia Rating (CDR), and subjects with normal cognitive function were defined as the normal control (NC) group. All patients underwent fMRI to identify the amplitude low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) values, and to analyze their association with VaMCI. The results showed that the VaMCI group had lower scores for Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and their subitems (visual space and execution, recall, attention and computation, and language ability) than NC group, with statistical differences (P < 0.05). In VaMCI group, the brain regions with increased ALFF values were the left temporal lobe, left parietal lobe, right temporal lobe, right parietal lobe, and posterior cingulate gyrus. Of them, the left parietal lobe and right temporal lobe were negatively correlated with the recall score on MMSE scale (r = -0.216, r = -0.132, P < 0.01). In VaMCI group, the brain regions with decreased ReHo values were the left temporal lobe, occipital lobe, and left middle temporal gyrus. Of them, the left temporal lobe and occipital lobe were positively correlated with MoCA score (r = 0.473, r = 0.848, P < 0.01). In conclusion, VaMCI patients have cognitive impairment and abnormally increased spontaneous brain activity, especially in the left parietal lobe and the right temporal lobe. At rest, VaMCI patients show decreased whole-brain ReHo in the left medial temporal lobe and occipital lobe. Hypertension is a high-risk factor for cognitive impairment in VaMCI patients. The study can provide a theoretical basis for early diagnosis of VaMCI.

Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb.

Seven previously undescribed diterpenoid alkaloids, including five C20-diterpenoid alkaloids, barpuberudine, barpubesines A-D, and two C18-diterpenoid alkaloids, barpubenines A-B, along with 11 known diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum Ledeb. (Ranunculaceae). Barpuberudine is an unprecedented carbon skeleton of C20-diterpenoid alkaloid, while barpubenines A-B are the first example of rearranged types in C18-diterpenoid alkaloids. Their structures were elucidated based on a comprehensive spectroscopic data analysis. The probable pathway of biogenesis of barpuberudine and barpubenines A-B were discussed. Additionally, the antiarrhythmic, cytotoxic and antimicrobial activities of isolates were also evaluated.